Thionyl Chloride → HCID 58087452, compound

Reaction equation

[CH2:1]([S:4]([NH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11](O)=[O:12])(=[O:6])=[O:5])[CH2:2][CH3:3].S(Cl)([Cl:19])=O>>[CH2:1]([S:4]([NH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([Cl:19])=[O:12])(=[O:6])=[O:5])[CH2:2][CH3:3]

Participants

Reactant 2

HCID 24386Thionyl Chloride

HCID 162282623-(Propane-1-sulfonamido)benzoic acid

Product 1

HCID 58087452HCID 58087452, compound

Procedure

A solution of 3-(propane-1-sulfonylamino)-benzoic acid (76, 1.20 g, 4.93 mmol) in thionyl chloride was heated to reflux for 3.0 hours. Evaporation of the solvent gave compound 77 as white solid that was used for the next step.

Workup

temperatureto reflux for 3.0 hours
customEvaporation of the solvent

Sources & evidence

ORD record: ord-5e4920dd7bd545bf8e68f5ef11f5b345
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07863288B2

Reaction notes

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