tert-Butyl isocyanate → 4-(tert-Butylureido)-N-{2-[4-(4-fluorobenzoyl)-piperidino]ethyl}-N-(2-methoxyphenyl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	tert-Butyl isocyanate	HCID 62412	—
Reactant	4-amino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide	HCID 19690043	—
Product	4-(tert-Butylureido)-N-{2-[4-(4-fluorobenzoyl)-piperidino]ethyl}-N-(2-methoxyphenyl)benzamide	HCID 19690014	77.6%

Reaction Steps

Using 4-amino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide (77.7 mg, 0.164 mmol) and tertbutyl isocyanate (0.022 ml, 0.196 mmol), the procedure of inventive Example 144 was repeated to obtain 72.9 mg (77.6%) of the title compound in a colorless oily form.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05728835
Source dataset	uspto-grants-1998_03
ORD ID	ord-13297e7c81bb418aa27b32cfac5bc697
Source note	uspto-grants-1998_03