3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile → 3-(6-(Methylamino)imidazo[1,2-b]pyridazin-2-yl)benzonitrile

HRID 251812

Reaction equation

Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[N:10]=2)[N:7]=1.CO.[CH3:21][NH2:22]>>[CH3:21][NH:22][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[N:10]=2)[N:7]=1

Participants

Reactant 2

HCID 468355643-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile

HCID 57454252Monomethylamine methanol

Product 1

HCID 665874053-(6-(Methylamino)imidazo[1,2-b]pyridazin-2-yl)benzonitrile

Conditions

Temperature: 125 °C

Procedure

A mixture of 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile (0.25 mmol) and 10 mL methylamine methanol solution was heated at 125° C. in microwave synthesizer for 30 min. After purification to provide 3-(6-(methylamino)imidazo[1,2-b]pyridazin-2-yl)benzonitrile.

Workup

customAfter purification

Sources & evidence

ORD record: ord-d13bd094e6e94c3e931b6535e20e553c
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07868001B2

Linked notes

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