3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile → 3-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile

HRID 251823

Reaction equation

HRID 251823 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[N:10]=2)[N:7]=1>CN(C=O)C.C1COCC1.[Pd]>[N:10]1[C:9]([C:11]2[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=2)[C:14]#[N:15])=[CH:8][N:6]2[C:5]=1[CH:4]=[CH:3][CH:2]=[N:7]2

Participants

4

Reactant 1

HCID 468355643-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile

Product 1

HCID 534394773-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrileYield 88.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21974620tetrahydrofuran N,N-dimethylformamideSolvent

Procedure

A mixture of 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile (1 mmol) and Pd/C (20 mg) in DMF/THF (10 ml/10 ml) was stirred at r.t. for 6 h equipped with a H2 balloon. Then the solvent was removed under reduced pressure and 3-(imidazo[1,2-b]pyridazin-2-yl)benzonitrile was obtained with a yield of 88.5%.

Workup

  1. customequipped with a H2 balloon
  2. customThen the solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-30420b1878484dd684c15607236eb653
Source dataset
uspto-grants-2011_01
Patent number
US07868001B2

Linked notes

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