HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-Benzoylamino-N-[2-(4-benzoylpiperidino)ethyl]-N-(3-pyridyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | 5-HT2A antagonist 1 | HCID 9888832 | — |
| Product | 4-Benzoylamino-N-[2-(4-benzoylpiperidino)ethyl]-N-(3-pyridyl)benzamide | HCID 19689888 | 85.9% |
Reaction Steps
Using 4-amino-N-[2-(4-benzoylpiperidino)ethyl]-N-(3-pyridyl)benzamide (210.7 mg, 0.49 mmol), benzoyl chloride (0.07 ml, 0.60 mmol) and pyridine (0.05 ml, 0.62 mmol), the procedure of Inventive Example 165 was repeated to obtain 224.3 mg (85.9%) of the title compound in a colorless powder form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05728835 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-df4b0db0bdde491cb5906e69e4e16de2 |
| Source note | uspto-grants-1998_03 |