4-Chloro-2-fluorobenzamide → 2-Benzylsulphanyl-4-chlorobenzamide
Reaction equation
[CH2:1]([S:8][C:9]1[CH:17]=[CH:16][C:15](Cl)=[CH:14][C:10]=1[C:11]([NH2:13])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:19]C1C=CC(C(N)=O)=C(F)C=1>>[CH2:1]([S:8][C:9]1[CH:17]=[C:16]([Cl:19])[CH:15]=[CH:14][C:10]=1[C:11]([NH2:13])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
3
Procedure
A method similar to the preparation of 2-benzylsulphanyl-5-chlorobenzamide (see page 17 above) was followed using 4-chloro-2-fluorobenzamide (400 mg, 2.31 mmol). The title compound was isolated as a white solid (376 mg, 59%).
Sources & evidence
- ORD record
- ord-7c508bd62d184e2ba5987411ef98d76d
- Source dataset
- uspto-grants-2011_01
- Patent number
- US07868017B2
Reaction notes
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