Reaction equation
[C:1]([NH:4][C:5]1[CH:38]=[CH:37][C:8]([C:9]([N:11]([CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH:25]([C:28](=[O:36])[C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)[CH2:24][CH2:23]2)[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=2)=[O:10])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[C:39]([OH:48])(=[O:47])[CH:40]([CH:42]([C:44]([OH:46])=[O:45])[OH:43])[OH:41]>>[C:39]([OH:48])(=[O:47])[CH:40]([CH:42]([C:44]([OH:46])=[O:45])[OH:43])[OH:41].[C:1]([NH:4][C:5]1[CH:38]=[CH:37][C:8]([C:9]([N:11]([CH2:20][CH2:21][N:22]2[CH2:23][CH2:24][CH:25]([C:28](=[O:36])[C:29]3[CH:30]=[CH:31][C:32]([F:35])=[CH:33][CH:34]=3)[CH2:26][CH2:27]2)[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[CH:13]=2)=[O:10])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]Participants
3
Procedure
Using 4-acetylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide (155.0 mg, 0.30 mmol) and tartaric acid (35.0 mg, 0.30 mmol), the procedure of Inventive Example 211 was repeated to obtain 143.0 mg (75.3%) of the title compound in a colorless powder form.
Sources & evidence
- ORD record
- ord-f8098aa2891d4fcea8abf7e7fa4e55c8
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05728835
Linked notes
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