3-(Trifluoromethyl)benzaldehyde → HCID 22493681, compound

HRID 253346

Reaction equation

HRID 253346 reaction equation
[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17](C)=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1C=CC=CC=1.C/C(/C(C)=O)=N\O.[F:28][C:29]([F:39])([F:38])C1C=C(C=CC=1)C=O>>[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:15]=[CH:16][CH:17]=[C:18]([C:29]([F:39])([F:38])[F:28])[CH:19]=2)[O:6][C:7]=1[CH3:8]

Participants

4

Reactant 3

HCID 679903-(Trifluoromethyl)benzaldehydeHCID 64096332,3-Butanedione monoximeHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 22493681HCID 22493681, compound

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, diacetylmonoxime and 3-trifluoromethylbenzaldehyde gave 4-iodomethyl-5-methyl-2-(3-trifluoromethylphenyl)oxazole.

Sources & evidence

ORD record
ord-b9be624fc4494ee897142306baafa463
Source dataset
uspto-grants-2011_01
Patent number
US07872034B2

Linked notes

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