Iodine → ethyl (NZ)-N-[4-butyl-2-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-thiazol-5-ylidene]carbamate

HRID 253665

Reaction equation

[CH:1](=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[F:8][C:9]([F:15])([F:14])[C:10]([CH3:13])([NH2:12])[CH3:11].[C:16]([N:21]=[C:22]=[S:23])(=[O:20])[O:17][CH2:18][CH3:19].II>>[CH2:3]([C:2]1=[CH:1][N:12]([C:10]([CH3:13])([CH3:11])[C:9]([F:15])([F:14])[F:8])[S:23]/[C:22]/1=[N:21]\[C:16](=[O:20])[O:17][CH2:18][CH3:19])[CH2:4][CH2:5][CH3:6]

Participants

Reactant 4

HCID 807Iodine

HCID 6184Hexanal

HCID 85320Ethyl isothiocyanatoformate

HCID 112751881,1,1-Trifluoro-2-methylpropan-2-amine

Product 1

HCID 87184182ethyl (NZ)-N-[4-butyl-2-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-thiazol-5-ylidene]carbamate

Procedure

Commercially available hexanal (Aldrich), 1,1,1-trifluoro-2-methylpropan-2-amine (Chemcollect), O-ethyl carbonisothiocyanatidate (Aldrich) and iodine were processed using the method described in Example 110A to afford the title compound. MS (ESI+) m/z 339 (M+H)+.

Sources & evidence

ORD record: ord-4288e9071d894b849c100c13d51a098f
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07872033B2

Linked notes

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