3-Fluorobenzenesulfonyl Chloride → 3-fluoro-N-(3-iodo-1H-indazol-5-yl)benzenesulfonamide

HRID 25370

Reaction equation

HRID 25370 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[I:11].[F:12][C:13]1[CH:14]=[C:15]([S:19](Cl)(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1>N1C=CC=CC=1>[F:12][C:13]1[CH:14]=[C:15]([S:19]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][N:6]=[C:5]3[I:11])(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 178507363HCID 178507363, compound

Product 1

HCID 1785274633-fluoro-N-(3-iodo-1H-indazol-5-yl)benzenesulfonamideYield 10.8%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-Fluoro-N-(3-iodo-1H-indazol-5-yl)benzenesulfonamide can be obtained as described in Example 2 from 230 mg of 5-amino-3-iodo-1H-indazole, 5 ml of pyridine and 173 mg of 3-fluorobenzenesulfonyl chloride. 40 mg of 3-fluoro-N-(3-iodo-1H-indazol-5-yl)benzenesulfonamide are thus obtained in the form of a cream solid melting at 189° C.

Sources & evidence

ORD record
ord-601f59a7f2504c518122b659c0f975ac
Source dataset
uspto-grants-2005_02
Patent number
US06858638B2

Linked notes

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