Ammonia → HCID 178507363, compound

HRID 25371

Reaction equation

HRID 25371 reaction equation
[I:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([N+:11]([O-])=O)[CH:9]=2)[NH:4][N:3]=1.C(O)C.O.N>C(OCC)(=O)C.ClCCl>[NH2:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][N:3]=[C:2]2[I:1]

Participants

6

Reactant 4

HCID 222AmmoniaHCID 702EthanolHCID 962WaterHCID 178526495HCID 178526495, compound

Product 1

HCID 178507363HCID 178507363, compoundYield 25.7%

Reagents, catalysts & solvents 1

HCID 21226138Dichloromethane ethylacetateSolvent

Procedure

5-Amino-3-iodo-1H-indazole can be obtained as described in Example 4 from 1 g of 3-iodo-5-nitro-1H-indazole, 20 ml of ethanol, 6.9 g of ferrous sulfate, 10.8 ml of distilled water and 8.2 ml of 32% aqueous ammonia. 230 mg of 5-amino-3-iodo-1H-indazole are thus obtained in the form of a yellow foam (Rf=0.12, silica gel thin layer chromatography, eluent: ethyl acetate/dichloromethane (2/8 by volume)).

Sources & evidence

ORD record
ord-99a073bb0a594f1b8fbc672a6e56d23e
Source dataset
uspto-grants-2005_02
Patent number
US06858638B2

Linked notes

Loading…