3-Fluorobenzenesulfonyl Chloride → HCID 178527464, compound

HRID 25375

Reaction equation

HRID 25375 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[OH:11].[F:12][C:13]1[CH:14]=[C:15]([S:19](Cl)(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1>N1C=CC=CC=1>[F:12][C:13]1[CH:14]=[C:15]([S:19]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][N:6]=[C:5]3[OH:11])(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 178507364HCID 178507364, compound

Product 1

HCID 178527464HCID 178527464, compoundYield 5.7%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3-Fluoro-N-(3-hydroxy-1H-indazol-5-yl)benzenesulfonamide can be obtained as described in Example 2 from 51 mg of 5-amino-3-hydroxy-1H-indazole, 1.5 ml of pyridine and 69 mg of 3-fluorobenzenesulfonyl chloride. 6 mg of 3-fluoro-N-(3-hydroxy-1H-indazol-5-yl)benzenesulfonamide are thus obtained in the form of a white solid.

Sources & evidence

ORD record
ord-a23b702c907c44d2b3c0ea777f25f57d
Source dataset
uspto-grants-2005_02
Patent number
US06858638B2

Linked notes

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