Ammonia → 5-amino-3-methylamino-1H-indazole
Reaction equation
[CH3:1][NH:2][C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N+:12]([O-])=O)[CH:10]=2)[NH:5][N:4]=1.C(O)C.N>O>[NH2:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[NH:5][N:4]=[C:3]2[NH:2][CH3:1]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
5-Amino-3-methylamino-1H-indazole can be obtained as described in Example 4 from 0.5 g of 3-methylamino-5-nitro-1H-indazole, 25 ml of ethanol, 5.2 g of ferrous sulfate, 8 ml of water and 6.2 ml of 32% aqueous ammonia. 0.1 g of 5-amino-3-methylamino-1H-indazole is thus obtained in the form of a cream powder melting at 215° C.
Sources & evidence
- ORD record
- ord-c7e26bb39a09469a8f0ab0cb3a1cbfe4
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06858638B2
Reaction notes
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