Hexahydro-1,4-diazepine → HCID 66852558, compound
Reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1)(=[O:13])=[O:12])[CH:6]=[C:5]2[CH2:21]Cl.[NH:23]1[CH2:29][CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:11]([C:14]1[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=1)(=[O:13])=[O:12])[CH:6]=[C:5]2[CH2:21][N:23]1[CH2:29][CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1Participants
3
Procedure
Using essentially the same procedure as described in example 127, 5-Bromo-1-(4-methylbenzenesulfonyl)-3-chloromethyl-1H-indole was reacted with homopiperazine to obtain the above derivative.
Workup
- customto obtain the above derivative
Sources & evidence
- ORD record
- ord-12c25de786654aedb9065f2bc5517a1f
- Source dataset
- uspto-grants-2011_01