Ethylenediamine → 2-(2-Fluoro-5-methyl-benzyl)-4,5-dihydro-1H-imidazole

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[CH2:9][C:10]#[N:11].[CH2:12](N)[CH2:13][NH2:14]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[CH2:9][C:10]1[NH:14][CH2:13][CH2:12][N:11]=1

Participants

Reactant 2

HCID 3301Ethylenediamine

HCID 177506762-Fluoro-5-methylphenylacetonitrile

Product 1

HCID 589517832-(2-Fluoro-5-methyl-benzyl)-4,5-dihydro-1H-imidazole

Procedure

2-(2-Fluoro-5-methyl-benzyl)-4,5-dihydro-1H-imidazole was prepared from (2-fluoro-5-methyl-phenyl)-acetonitrile and ethylene diamine in analogy to Example 19 b): light yellow powder; MS (ISP): 193.0 ((M+H)+.).

Sources & evidence

ORD record: ord-980ccfae48f64b4ba8f89b76d5dce4b1
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07875645B2

Reaction notes

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