Ethylenediamine → 2-(2,6-Difluoro-3-methyl-benzyl)-4,5-dihydro-1H-imidazole

Reaction equation

[F:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[CH2:10][C:11]#[N:12].[CH2:13](N)[CH2:14][NH2:15]>>[F:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[CH2:10][C:11]1[NH:15][CH2:14][CH2:13][N:12]=1

Participants

Reactant 2

HCID 3301Ethylenediamine

HCID 27741582,6-Difluoro-3-Methylphenylacetonitrile

Product 1

HCID 589518602-(2,6-Difluoro-3-methyl-benzyl)-4,5-dihydro-1H-imidazole

Procedure

2-(2,6-Difluoro-3-methyl-benzyl)-4,5-dihydro-1H-imidazole was prepared from (2,6-difluoro-3-methyl-phenyl)-acetonitrile and ethylene diamine in analogy to Example 19 b): colourless powder; MS (ISP): 210.1 ((M+H)+.).

Sources & evidence

ORD record: ord-841ad183ec5344268c400db20bffe5e5
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07875645B2

Reaction notes

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