Ethylenediamine → 2-[1-(2-bromophenyl)ethyl]-4,5-dihydro-1H-imidazole

HRID 254523

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([CH3:11])[C:9]#[N:10].[CH2:12](N)[CH2:13][NH2:14]>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([C:9]1[NH:14][CH2:13][CH2:12][N:10]=1)[CH3:11]

Participants

Reactant 2

HCID 3301Ethylenediamine

HCID 106084942-(2-Bromophenyl)propanenitrile

Product 1

HCID 589517312-[1-(2-bromophenyl)ethyl]-4,5-dihydro-1H-imidazole

Procedure

rac-2-[1-(2-Bromo-phenyl)-ethyl]-4,5-dihydro-1H-imidazole was prepared from rac-2-(2-bromo-phenyl)-propionitrile and ethylene diamine in analogy to Example 19 b): off-white solid; MS (EI): 251.0 and 253.0 (M+.), 173.1 (((M-Br)+.), 100%).

Sources & evidence

ORD record: ord-0428036f3a6542368c040aadcb9737ba
Source dataset: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07875645B2

Linked notes

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