HuagongsheHuagongshe Chemistry Print Report · For research reference only
Succinic Acid → Succinimide succinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Succinic Acid | HCID 1110 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | N-Hydroxysuccinimide | HCID 80170 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Succinic anhydride | HCID 7922 | — |
| Product | Succinimide succinate | HCID 66685880 | — |
Reaction Steps
As depicted in above Scheme 4, 6-arm PEG (1) synthesized in the Scheme 1 is reacted with succinic reagents, e.g., succinic anhydride and toluene as solvent to synthesize 6-arm PEG-succinic acid (6-arm PEG-SA) (6). The 6-arm PEG SA (6) is reacted with N-hydroxy succinimide (NHS) and N, N′-dicyclohexylcarbodiimide (DCC) to produce 6-arm PEG-succinimide succinate (6-arm PEG-SS) (7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06858736B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-1a7ed486abdf44a381336bc9e5bad0ba |
| Source note | uspto-grants-2005_02 |