4-Methoxy-2-nitrobenzoic acid → 2-Amino-4-methoxybenzoic acid
Reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[C:5]([N+:12]([O-])=O)[CH:4]=1>[Pd].CO>[NH2:12][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
4-Methoxy-2-nitrobenzoic acid (3 g, 16.4 mmol) was hydrogenated over palladium on carbon (10%, 300 mg) in methanol (80 mL) at room temperature and normal pressure for 18 hours. The reaction mixture was filtered through celite and concentrated to dryness under reduce pressure to give 2.50 g (100%) of the product as a colorless solid.
Workup
- filtrationThe reaction mixture was filtered through celite and
- concentrationconcentrated to dryness
Sources & evidence
- ORD record
- ord-f8f4666ef20642c2a03ae86bb6637376
- Source dataset
- uspto-grants-2011_01
- Patent number
- US07875715B2
Reaction notes
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