1-(2-Nitro-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane → 1-(2-Amino-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane

HRID 255461

Reaction equation

HRID 255461 reaction equation
[N+:1]([C:4]([CH3:17])([CH3:16])[CH2:5][O:6][CH:7]1[C:11]([CH3:13])([CH3:12])[CH2:10][CH2:9][C:8]1([CH3:15])[CH3:14])([O-])=O>CO.[Ni]>[NH2:1][C:4]([CH3:17])([CH3:16])[CH2:5][O:6][CH:7]1[C:11]([CH3:13])([CH3:12])[CH2:10][CH2:9][C:8]1([CH3:15])[CH3:14]

Participants

4

Reactant 1

HCID 201657161-(2-Nitro-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane

Product 1

HCID 201657551-(2-Amino-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

1-(2-Nitro-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane is dissolved in methanol and hydrogenated at 50 psi with Raney nickel T-1 as a catalyst. The reaction mixture is filtered through Celite and evaporated to yield 1-(2-amino-2-methylpropoxy)-2,2,5,5-tetramethylcyclopentane.

Workup

  1. filtrationThe reaction mixture is filtered through Celite
  2. customevaporated

Sources & evidence

ORD record
ord-072cd696dd184a92a527b40d5e77fb5d
Source dataset
uspto-grants-1987_10
Patent number
US04698231

Linked notes

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