4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline → HCID 11357280, compound

HRID 255554

Reaction equation

HRID 255554 reaction equation
Cl[C:2]1[C:11]2[N:12]=[CH:13][N:14]([CH2:15][CH:16]([CH3:18])[CH3:17])[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[CH3:19][O-:20].[Na+]>>[CH2:15]([N:14]1[C:10]2[C:9]3[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=3[N:3]=[C:2]([O:20][CH3:19])[C:11]=2[N:12]=[CH:13]1)[CH:16]([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 3839614-chloro-1-isobutyl-1H-imidazo[4,5-c]quinolineHCID 10942334Sodium Methoxide

Product 1

HCID 11357280HCID 11357280, compound

Procedure

Using the method of Example 157, 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline (from Example 96) was reacted with sodium methoxide to provide 1-isobutyl-4-methoxy-1H-imidazo[4,5-c]quinoline, melting point 111°-114° C. after sequential recrystallizations from aqueous ethanol and diethyl ether. Analysis: Calculated for C15H17N3O: %C, 70.6; %H, 6.7; %N, 16.5; Found: %C, 70.6; %H, 6.7; %N, 16.5.

Sources & evidence

ORD record
ord-4d884ff3b7694c9ea00ae819e8fc77c3
Source dataset
uspto-grants-1987_10
Patent number
US04698348

Linked notes

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