Stearic Acid → Azulenesulfonic acid
Reaction equation
[C:1]1([S:11]([O-:14])(=[O:13])=[O:12])[C:10]2[C:4]([CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[CH:3][CH:2]=1.[Na+].C(O)(=O)CCCCCCCCCCCCCCCCC>>[C:1]1([S:11]([OH:14])(=[O:12])=[O:13])[C:10]2[C:4]([CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=2)=[CH:3][CH:2]=1Participants
3
Conditions
- Temperature
- 80 °C
Procedure
Sodium azulenesulfonate (12 g), 186 g of hydroxypropylcellulose-M and 282 g of stearic acid were granulated by the same way as in Example 5. Each 160 mg of it was filled in a capsule No. 3. The capsules were placed in a fluidized bed granulator-drier, fluidized by heating with air (intake temperature: 80° C.) for 15 minutes, the heater was turned off and allowed to cool with air of the room temperature to give capsules each containing 4 mg of azulenesulfonic acid.
Workup
- addition