Acetic Acid → HCID 14405001, compound
Reaction equation
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([Cl:10])[C:3]=1[OH:11].C(O)(=O)C.[N+:16]([O-])([OH:18])=[O:17]>ClCCl>[Cl:1][C:2]1[C:7]([F:8])=[C:6]([N+:16]([O-:18])=[O:17])[C:5]([F:9])=[C:4]([Cl:10])[C:3]=1[OH:11]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
20 g of 2,6-dichloro-3,5-difluorophenol are introduced into 70 ml of acetic acid, and 8 g of 98% strength nitric acid are added dropwise. The mixture is subsequently stirred for a further 2 hours at room temperature and taken up in 150 ml of dichloromethane, and the solution is washed twice with water. After removing the dichloromethane by distillation, 18 g of product remain. 94% purity according to GC analysis.
Workup
- additionare added dropwise
- washthe solution is washed twice with water
- customAfter removing the dichloromethane
- distillationby distillation, 18 g of product
Sources & evidence
- ORD record
- ord-ea06658fa5aa4b67a80ea6d01647b260
- Source dataset
- uspto-grants-1993_11
- Patent number
- US05260474
Reaction notes
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