n-Methyl-3-nitropyridin-4-amine → 4-N-methylpyridine-3,4-diamine
Reaction equation
[N+:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[NH:10][CH3:11])([O-])=O>C(O)C.[Pt]=O>[NH2:1][C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[NH:10][CH3:11]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
150 mg of platinum oxide was added to 10 ml of a solution of 3-nitro-4-methylaminopyridine (1.5 g) in ethanol. The mixture was stirred under a hydrogen atmosphere at room temperature for 7.5 hours. Platinum oxide was removed by filtration, and the filtrate was concentrated. Thus, 962 mg (yield: 80%) of the intended product was obtained as brown crude crystals.
Workup
- customPlatinum oxide was removed by filtration
- concentrationthe filtrate was concentrated
Sources & evidence
- ORD record
- ord-484ff4d8aee143319be9cb8ee8336d05
- Source dataset
- uspto-grants-1993_11
- Patent number
- US05262415
Reaction notes
Loading…