4-Ethylpyridine → 1-(3-Chlorophenyl)-3-(4-pyridyl)-butane

Reaction equation

[CH2:1]([C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1)[CH3:2].[Cl:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][CH:18]=1)[CH2:13][CH2:14]Br>>[Cl:9][C:10]1[CH:11]=[C:12]([CH2:13][CH2:14][CH:1]([C:3]2[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=2)[CH3:2])[CH:16]=[CH:17][CH:18]=1

Participants

Reactant 2

HCID 108224-Ethylpyridine

HCID 1401401-(2-Bromoethyl)-3-chlorobenzene

Product 1

HCID 197833641-(3-Chlorophenyl)-3-(4-pyridyl)-butaneYield 28.3%

Procedure

1.0 g (9.35 mmol) of 4-ethylpyridine and 2.05 g (9.35 mmol) of 3-chlorophenethyl bromide were reacted in the same manner as in Example 1. The reaction product was purified to obtain 0.65 g of the desired compound (yield: 28.2%).

Workup

customThe reaction product was purified

Sources & evidence

ORD record: ord-b44d2b926edc42f4a93bced206e96fe7
Source dataset: uspto-grants-1993_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05262420

Reaction notes

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