4-Nitro-alpha,alpha,alpha-trifluoro-o-toluidine → 2-Nitro-alpha,alpha,alpha-trifluorotoluene

HRID 257601

Reaction equation

HRID 257601 reaction equation
[N+](C1C=CC(N)=C(C(F)(F)F)C=1)([O-])=O.[N+:15]([C:18]1[CH:24]=[CH:23][C:21](N)=[CH:20][C:19]=1[C:25]([F:28])([F:27])[F:26])([O-:17])=[O:16]>>[F:26][C:25]([F:27])([F:28])[C:19]1[CH:20]=[CH:21][CH:23]=[CH:24][C:18]=1[N+:15]([O-:17])=[O:16]

Participants

3

Reactant 2

HCID 671284-Nitro-alpha,alpha,alpha-trifluoro-o-toluidineHCID 949554-Nitro-3-(trifluoromethyl)aniline

Product 1

HCID 97952-Nitro-alpha,alpha,alpha-trifluorotoluene

Procedure

The precipitate was filtered and air-dried to give 3.5 g (85%) of the product which had a melting point of 85°-89° C. It consisted of 92-93% of the required 4-nitro-2-trifluoromethylaniline which was contaminated with 4-nitro-3-trifluoromethylaniline produced from the 2-trifluoromethylnitrobenzene which had contaminated the starting material. According to 1H-NMR (200 MHz) the product contained less than 1% of the disulphide.

Sources & evidence

ORD record
ord-04b299dd66bf42adb4eeacdd21eac235
Source dataset
uspto-grants-1993_11
Patent number
US05262539

Linked notes

Loading…