1,1'-(Diazomethylene)bis(benzene) → Diphenylmethyl [4-cyano-2,3-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]-bromoacetate

HRID 2577

Reaction equation

HRID 2577 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([Br:13])[C:10]([OH:12])=[O:11])=[C:5]([O:14][CH2:15][O:16][CH2:17][CH2:18][O:19][CH3:20])[C:4]=1[O:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH3:27])#[N:2].[C:28]1([C:34]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[N+]=[N-])[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>C(Cl)Cl>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([Br:13])[C:10]([O:12][CH:34]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)=[O:11])=[C:5]([O:14][CH2:15][O:16][CH2:17][CH2:18][O:19][CH3:20])[C:4]=1[O:21][CH2:22][O:23][CH2:24][CH2:25][O:26][CH3:27])#[N:2]

Participants

4

Reactant 2

HCID 612301,1'-(Diazomethylene)bis(benzene)HCID 18359186[4-Cyano-2,3-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]bromoacetic acid

Product 1

HCID 53964381Diphenylmethyl [4-cyano-2,3-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]-bromoacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product of Step A was dissolved in 10 ml of methylene chloride and 470 mg of diphenyl diazomethane were added. Evaporation was carried out followed by chromatography on silica (eluant: cyclohexane - ethyl acetate (2-1)) to obtain 450 mg of the desired, product.

Workup

  1. customEvaporation
  2. customto obtain 450 mg of the

Sources & evidence

ORD record
ord-9e556f57e168442bbbc24bcb8ff4afba
Source dataset
uspto-grants-1998_03
Patent number
US05728828

Linked notes

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