4-Bromobutyryl chloride → 5-(4-Diethylamino-butyryl)-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one

HRID 257745

Reaction equation

HRID 257745 reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]([N:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[C:11](=[O:18])[NH:10][C:9]2[CH:19]=[CH:20][CH:21]=[CH:22][C:8]1=2)=[O:6].C1C2C(=O)N[C:30]3C=CC=C[C:29]=3[NH:28][C:27]=2[CH:26]=CC=1.BrCCCC(Cl)=O>C1(C)C=CC=CC=1>[CH2:27]([N:28]([CH2:29][CH3:30])[CH2:2][CH2:3][CH2:4][C:5]([N:7]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[C:11](=[O:18])[NH:10][C:9]2[CH:19]=[CH:20][CH:21]=[CH:22][C:8]1=2)=[O:6])[CH3:26]

Participants

5

Reactant 3

HCID 702254-Bromobutyryl chlorideHCID 2013275,10-Dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-oneHCID 107371515-(4-bromobutyryl)-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one

Product 1

HCID 151154995-(4-Diethylamino-butyryl)-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The 5-(4-bromobutyryl)-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one, starting material, was synthesized similarly to the starting material described in Example 1, from 5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one and 4-bromobutyryl chloride. The yield is 74.3% of the theoretical yield and the melting point is 159°-161° C. (toluene).

Workup

  1. customwas synthesized similarly to the starting material
  2. customThe yield is 74.3% of the theoretical yield

Sources & evidence

ORD record
ord-d7b8681b86894f4c8a6680f86fef89c1
Source dataset
uspto-grants-1993_11
Patent number
US05264432

Linked notes

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