4-Bromobutyryl chloride → 8-Chloro-5-(4-diethylamino-butyryl)-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one

HRID 257746

Reaction equation

HRID 257746 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](=[O:16])[NH:7][C:6]=2[CH:17]=1.Br[CH2:19][CH2:20][CH2:21][C:22](Cl)=[O:23]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]([C:22](=[O:23])[CH2:21][CH2:20][CH2:19][N:7]([CH2:8][CH3:9])[CH2:6][CH3:5])[C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[C:8](=[O:16])[NH:7][C:6]=2[CH:17]=1

Participants

3

Reactant 2

HCID 702254-Bromobutyryl chlorideHCID 36531168-chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Product 1

HCID 106678378-Chloro-5-(4-diethylamino-butyryl)-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one

Procedure

The 5-(5-bromobutyryl)-8-chloro-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one, used as starting material, is synthesized similarly to the starting material described in Example 1 from 8-chloro-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one and 4-bromobutyryl chloride. The yield is 83.1% of the theoretical yield and the melting point is 176°-177° C.

Workup

  1. customis synthesized similarly to the starting material
  2. customThe yield is 83.1% of the theoretical yield

Sources & evidence

ORD record
ord-d3b24c7feeb842ad93fc96aa34fb579e
Source dataset
uspto-grants-1993_11
Patent number
US05264432

Linked notes

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