5-Bromovaleryl chloride → 8-Chloro-5-(5-diethylamino-valeryl)-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one

HRID 257747

Reaction equation

HRID 257747 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([N:8]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[C:12](=[O:19])[NH:11][C:10]2[CH:20]=[C:21]([Cl:24])[CH:22]=[CH:23][C:9]1=2)=[O:7].ClC1C=C[C:29]2NC3C=CC=C[C:33]=3[C:32](=O)[NH:31][C:30]=2C=1.BrCCCCC(Cl)=O>>[Cl:24][C:21]1[CH:22]=[CH:23][C:9]2[N:8]([C:6](=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2][N:31]([CH2:32][CH3:33])[CH2:30][CH3:29])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=3[C:12](=[O:19])[NH:11][C:10]=2[CH:20]=1

Participants

4

Reactant 3

HCID 5211735-Bromovaleryl chlorideHCID 36531168-chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-oneHCID 105254765-(5-bromovaleryl)-8-chloro-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one

Product 1

HCID 105489658-Chloro-5-(5-diethylamino-valeryl)-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one

Procedure

The 5-(5-bromovaleryl)-8-chloro-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one, used as starting material, is synthesized similarly to the starting material described in Example 1, from 8-chloro-5,10-dihydro-11H-dibenzo(b,e)(1,4)-diazepine-11-one and 5-bromovaleryl chloride.

Workup

  1. customis synthesized similarly to the starting material

Sources & evidence

ORD record
ord-b8cb9c71c6ea45d89fcd56979a5d8b8f
Source dataset
uspto-grants-1993_11
Patent number
US05264432

Linked notes

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