Methyl iodide → 3-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

HRID 257885

Reaction equation

HRID 257885 reaction equation
[CH3:1][I:2].[CH:3]1([CH2:6][O:7][C:8]2[C:9]([C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)=[N:10][S:11][N:12]=2)[CH2:5][CH2:4]1>CC(C)=O>[I-:2].[CH:3]1([CH2:6][O:7][C:8]2[C:9]([C:13]3[CH:14]=[N+:15]([CH3:1])[CH:16]=[CH:17][CH:18]=3)=[N:10][S:11][N:12]=2)[CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 190752393-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)pyridine

Product 1

HCID 190754673-(3-Cyclopropylmethoxy-1,2,5-thiadiazol-4-yl)-1-methylpyridinium iodide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of methyl iodide (0.25 ml, 4 mmol) and 3-(4-cyclopropylmethoxy-1,2,5-thiadiazol-3-yl)pyridine (400 mg, 1.7 mmol) in acetone (5 ml) was stirred at room temperature for 36 h. The title compound precipitated from the solution and was collected by filtration to yield 0.41 g (65%).

Workup

  1. customThe title compound precipitated from the solution
  2. filtrationwas collected by filtration
  3. customto yield 0.41 g (65%)

Sources & evidence

ORD record
ord-5f64e9344351441bb32b67183e46a539
Source dataset
uspto-grants-1993_11
Patent number
US05264444

Linked notes

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