Pyridine → S-Methylglutathione

HRID 258234

Reaction equation

HRID 258234 reaction equation
[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4].N1C=CC=C[CH:22]=1>>[CH3:22][S:13][CH2:12][C@@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[NH:10][C:8](=[O:9])[CH2:7][CH2:6][C@@H:2]([C:3]([OH:5])=[O:4])[NH2:1]

Participants

3

Reactant 2

HCID 1049PyridineHCID 124886Glutathione

Product 1

HCID 115260S-Methylglutathione

Procedure

When glutathione was complexed with Cr(II), no measurable oxidation of the Cr(II) was observed until the appropriate pyridine derivative was added to the complex mixture. At this time, the 280 nm-340 nm charge transfer peak also appeared. At no time were the 450 nm and 585 nm peaks attributable to Cr--S observed. Replacing glutathione with S-methylglutathione gave identical results.

Workup

  1. additionwas added to the complex mixture
  2. additionAt this time, the 280 nm-340 nm charge transfer peak

Sources & evidence

ORD record
ord-0f98d2e79fb94967b51a506e029bc6aa
Source dataset
uspto-grants-1993_11
Patent number
US05266560

Linked notes

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