Ethanol → (+)-p-(2-Thenoyl)hydratropic acid alpha-methylbenzylamine

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Reaction Steps

To a stirred mixture of 20 parts of p-(2-thenoyl)hydratropic acid and 9.3 parts of (-)-α-methylbenzylamine in 200 parts of ethanol are added 50 parts of water. The precipitated salt is filtered off and crystallized from a mixture of ethanol and water (10 : 2 by volume), yielding the crude salt form. This fraction is recrystallized several times till constant rotation, from a mixture of ethanol and water (10 : 2 by volume), to yield (-)-p-(2-thenoyl)hydratropic acid α-methyl-benzylamine; m.p. 170.5° C; [α](1.98% MeOH)= -13.74° .

Provenance & Evidence