2-(1H-Pyrrol-1-Yl)Phenol → Pyrrolo[2,1-c][1,4]benzoxazine-4-acetic acid ethyl ester
Reaction equation
O[C:2]1C=CC=C[C:3]=1N1C=CC=C1.ClC1C=CC(O)=C(N2C=CC=C2)C=1.Cl[C:27]1[CH:28]=[CH:29][C:30]2[O:35][C:34](C)([CH2:36][C:37]([OH:39])=[O:38])[C:33]3=[CH:41][CH:42]=[CH:43][N:32]3[C:31]=2[CH:44]=1>>[CH2:2]([O:39][C:37](=[O:38])[CH2:36][C:34]1[O:35][C:30]2[CH:29]=[CH:28][CH:27]=[CH:44][C:31]=2[N:32]2[CH2:43][CH:42]=[CH:41][C:33]=12)[CH3:3]Participants
4
Procedure
In the same manner but replacing N-(2-hydroxyphenyl)pyrrole with an equivalent amount of N-(5-chloro-2-hydroxyphenyl)pyrrole, described in Example 1, 8-chloro-4-methyl-4H-pyrrolo[2,1-c][1,4]-benzoxazine-4-acetic acid, νmaxCHCl3 2,900 - 2,500, 1,728, 1,498, 1,445 cm-1, is obtained via the intermediate ester, 8-chloro-4-methyl-4H-, pyrrolo[2,1-c][1,4]benzoxazine-4-acetic acid ethyl ester, νmaxCHCl3 1,732 cm-1.