1-Piperazinecarboxylic acid, ethyl ester → HCID 21423023, compound

Reaction equation

[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])[CH3:2].CS(O[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])(=O)=O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH2:1]([O:3][C:4]([N:6]1[CH2:7][CH2:8][N:9]([CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH3:17])[CH2:10][CH2:11]1)=[O:5])[CH3:2]

Participants

Procedure

25.0 Grams of 1-ethoxycarbonylpiperazine, 43.0 grams of pentadecyl methylsulfonate, 250 ml. of ethanol, and 9.53 grams of sodium carbonate are combined and heated to gentle reflux. After refluxing for 6 hours, the mixture is filtered, and the solvents removed under reduced pressure. The residue is dissolved in a mixture of water and ethyl ether. The organic layer is separated, washed once with water, and dried over anhydrous magnesium sulfate and anhydrous sodium sulfate. The solvent is removed under reduced pressure to give 1-ethoxycarbonyl-4-pentadecylpiperazine.