3-Cyclobutene-1,2-dione, 3,4-dimethoxy- → HCID 21423016, compound

HRID 259074

Reaction equation

HRID 259074 reaction equation
CO[C:3]1[C:4](=O)[C:5](=[O:9])[C:6]=1[O:7]C.[CH2:11]([N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[CH2:12][CH2:13][CH3:14]>C(O)C>[CH2:11]([N:15]1[CH2:20][CH2:19][N:18]([C:3]2[C:6](=[O:7])[C:5](=[O:9])[C:4]=2[N:18]2[CH2:19][CH2:20][N:15]([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:16][CH2:17]2)[CH2:17][CH2:16]1)[CH2:12][CH2:13][CH3:14]

Participants

4

Reactant 2

HCID 1232273-Cyclobutene-1,2-dione, 3,4-dimethoxy-HCID 4243221-Butylpiperazine

Product 1

HCID 21423016HCID 21423016, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 0.9 grams of 3,4-dimethoxy-3-cyclobutene-1,2-dione dissolved in 10 ml. of absolute ethanol is added 1.8 grams of 1-butylpiperazine in 5 ml. of absolute ethanol. The reaction mixture is stirred overnight at room temperature under a nitrogen atmosphere. Then, the solvent is removed with a nitrogen stream, 5 ml. of anhydrous ethyl ether is added, and the resultant solid is filtered, washed with ethyl ether, and dried in air. The resulting product, 3,4-bis(4-butyl-1-piperazinyl)-3-cyclobutene-1,2-dione is obtained as white crystals melting at approximately 137.5°-139° C.

Workup

  1. customThen, the solvent is removed with a nitrogen stream, 5 ml
  2. additionof anhydrous ethyl ether is added
  3. filtrationthe resultant solid is filtered
  4. washwashed with ethyl ether
  5. customdried in air

Sources & evidence

ORD record
ord-a08643ed37f04634877d73a421a5cead
Source dataset
uspto-grants-1977_07
Patent number
US04036828

Linked notes

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