5-Methyl-1,2-oxazole-3-carbaldehyde → 1-{[(5-Methyl-1,2-oxazol-3-yl)methylidene]amino}imidazolidin-2-one
Reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([CH:7]=O)[CH:3]=1.Cl.[NH2:10][N:11]1[CH2:15][CH2:14][NH:13][C:12]1=[O:16]>O>[CH3:1][C:2]1[O:6][N:5]=[C:4]([CH:7]=[N:10][N:11]2[CH2:15][CH2:14][NH:13][C:12]2=[O:16])[CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
14.0 pts. by wt. of 5-methyl-3-formyl-isoxazole are reacted with 25.6 pts. by wt. of 1-amino-2-oxo-imidazolidine hydrochloride in 100 pts. by vol. of water as in Example 25.1. After 90 minutes, the precipitate is filtered off, washed with water, dried and recrystallised from absolute acetonitrile. 12.5 pts. by wt. of 1-(5-methyl-isoxazol-3-yl-methyleneamino)-2-oxo-imidazolidine of melting point 195°-7° C. are obtained.
Workup
- filtrationthe precipitate is filtered off
- washwashed with water
- customdried
- customrecrystallised from absolute acetonitrile
Sources & evidence
- ORD record
- ord-139d17def34245298714a3e2a6ba331f
- Source dataset
- uspto-grants-1979_04
- Patent number
- US04147693
Reaction notes
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