Sodium Hydroxide → L-Lysine

HRID 259411Notes

Reaction equation

HRID 259411 reaction equation
Cl.[NH2:2][C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][NH2:8].[OH-].[Na+]>C(O)C>[NH2:2][C@H:3]([C:9]([OH:11])=[O:10])[CH2:4][CH2:5][CH2:6][CH2:7][NH2:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69568L-Lysine monohydrochloride

Product 1

HCID 5962L-LysineYield 97.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Into the reaction apparatus used in Example 1, 160 g of ethyl alcohol, 18.3 g of lysine hydrochloride and 4.0 g of sodium hydroxide were charged. The resulting mixture was heated, refluxing the solvent, while being stirred, and was kept for 3 hours. The resultant product was cooled to room temperature and the by-product sodium chloride was filtered off therefrom. The solvent was distilled off from the obtained product to obtain 14.3 g of lysine in a syrup state. The lysine obtained, 15.8 g of allantoin and 150 ml of water were charged into the apparatus.

Workup

  1. additionwere charged
  2. temperatureThe resulting mixture was heated
  3. temperaturerefluxing the solvent
  4. filtrationthe by-product sodium chloride was filtered off
  5. distillationThe solvent was distilled off from the obtained product

Sources & evidence

ORD record
ord-26ef38e707344f00b1bbdc6e88b1c41d
Source dataset
uspto-grants-1977_07
Patent number
US04038287

Reaction notes

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