Ammonia → 4,5-Dimethoxy-2-methylbenzene-1-sulfonamide

Reaction equation

[S:1](Cl)([OH:4])(=O)=[O:2].[CH3:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][CH:8]=1.[NH3:17]>>[CH3:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][C:8]=1[S:1]([NH2:17])(=[O:4])=[O:2]

Participants

Reactant 2

HCID 222Ammonia

HCID 214222402-Methyl-4,5-dimethoxy-benzene sulfochloride

Product 1

HCID 352990334,5-Dimethoxy-2-methylbenzene-1-sulfonamide

Procedure

18 gm (0.07 mol) of the compound obtained in step (a) were suspended in 200 ml of concentrated ammonia, and the suspension was stirred at room temperature for 4 hours. Thereafter, the mixture was suction-filtered, the filter cake was washed with water, and the desired sulfonamide was obtained as an amorphous product after drying. Rf -value (benzene/acetone = 1/1): 0.6.

Workup

filtrationThereafter, the mixture was suction-filtered
washthe filter cake was washed with water

Sources & evidence

ORD record: ord-7d5928546b9b4978a1ec81d729dc8835
Source dataset: uspto-grants-1977_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04038407

Reaction notes

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