Bromine → 1-Bromo-3,3-dimethyl-1-phenylbutan-2-one

HRID 25964

Reaction equation

HRID 25964 reaction equation
[C:1]1([CH2:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:14]Br>C(Cl)(Cl)(Cl)Cl>[Br:14][CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:8](=[O:13])[C:9]([CH3:10])([CH3:12])[CH3:11]

Participants

4

Reactant 2

HCID 24408BromineHCID 101712813,3-Dimethyl-1-phenylbutan-2-one

Product 1

HCID 134586931-Bromo-3,3-dimethyl-1-phenylbutan-2-oneYield 99.5%

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

17.6 g (0.1 mol) of 1-phenyl-3,3-dimethyl-butan-2-one were dissolved in 100 ml of carbon tetrachloride, 5 ml (0.1 mole) of bromine were added dropwise thereto while stirring and under reflux, and the mixture was heated to the boil for one hour. After cooling, the distilling off the solvent, 25.4 g of 1-bromo-1-phenyl-3,3-dimethyl-butan-2-one of melting point 38°-42° C. were obtained in quantitative yield.

Workup

  1. temperatureunder reflux
  2. temperaturethe mixture was heated to the boil for one hour
  3. temperatureAfter cooling

Sources & evidence

ORD record
ord-f404599ab53b42d4923b6b07a99ec118
Source dataset
uspto-grants-1979_04
Patent number
US04147791

Linked notes

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