HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetonitrile → 1-Butylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone | HCID 23343637 | — |
| Product | 1-Butylpiperazine | HCID 424322 | — |
Reaction Steps
Following the procedure of Example 15 but starting with 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one (5.1 g.) and 1-t.-butylpiperazine (5 g.) in acetonitrile (31 cc.), 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(4-t.-butylpiperazin-1-yl)carbonyloxy-isoindolin-1-one (3.3 g.), melting at 240° C., is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04038391 |
| Source dataset | uspto-grants-1977_07 |
| ORD ID | ord-ccaf40d687bd4d68af52336ab49e1b83 |
| Source note | uspto-grants-1977_07 |