Trioctylamine → Methyl 2,3,4,5-tetrafluorobenzoate

HRID 259955

Reaction equation

HRID 259955 reaction equation
[CH3:1][O:2][C:3](=[O:17])[C:4]1[C:5](=[C:9]([F:16])[C:10]([F:15])=[C:11]([F:14])[C:12]=1[F:13])C(O)=O.C(N(CCCCCCCC)CCCCCCCC)CCCCCCC>>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:5]=[C:9]([F:16])[C:10]([F:15])=[C:11]([F:14])[C:12]=1[F:13]

Participants

3

Reactant 2

HCID 14227TrioctylamineHCID 108579443,4,5,6-Tetrafluorophthalic acid-monomethyl ester

Product 1

HCID 600996Methyl 2,3,4,5-tetrafluorobenzoateYield 94.3%

Conditions

Temperature
140 °C

Procedure

Into a 100 ml three necked flask, 20 g (0.079 mol) of the 3,4,5,6-tetrafluorophthalic acid-monomethyl ester prepared in Example 14, and 27.9 g (0.079 mol) of tri-n-octylamine were charged, and the mixture was heated and stirred at 140° C. for 4 hours. After completion of the reaction, the reaction mixture was separated by distillation to obtain 15.5 g of 2,3,4,5-tetrafluorobenzoic acid methyl ester. The yield was 94.2%.

Workup

  1. temperaturethe mixture was heated
  2. customAfter completion of the reaction
  3. customthe reaction mixture was separated by distillation

Sources & evidence

ORD record
ord-40409f7fad30481a8741d4469a92a16e
Source dataset
uspto-grants-1996_06
Patent number
US05523476

Linked notes

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