Ethanol → Ibuprofen, (+-)-

HRID 260385

Reaction equation

HRID 260385 reaction equation
[CH3:1][CH:2]([C:16]([OH:18])=[O:17])[C:3]1[CH:4]=[CH:5][C:6]([C:10]2[CH:11]=[CH:12]C=CC=2)=[C:7](F)[CH:8]=1.[CH2:19](O)C>>[OH:18][C:16]([CH:2]([C:3]1[CH:8]=[CH:7][C:6]([CH2:10][CH:11]([CH3:12])[CH3:19])=[CH:5][CH:4]=1)[CH3:1])=[O:17]

Participants

3

Reactant 2

HCID 702EthanolHCID 3394Flurbiprofen

Product 1

HCID 3672Ibuprofen, (+-)-

Conditions

Temperature
60 °C

Procedure

Three grams of flurbiprofen and 30 g of poloxamer 237 were heated at 110° C. for 10 minutes to obtain a liquified mixture and cooled to 60° C. Into this mixture, 5 g of polyethylene glycol 300, 10 g of ethanol and 52 g of pH 4 buffer solution were added at 60° C. to obtain an ibuprofen gel.

Workup

  1. customto obtain a liquified mixture

Sources & evidence

ORD record
ord-b0ad4fad120e4b30b6d002e81134c3db
Source dataset
uspto-grants-1996_06
Patent number
US05527832

Linked notes

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