2-Aminopyridine → N-Pyridin-2-yl-N'-1,2,3-thiadiazol-5-ylurea
Reaction equation
O([C:8]([NH:10][C:11]1[S:15][N:14]=[N:13][CH:12]=1)=[O:9])C1C=CC=CC=1.[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1>CC(C)=O>[N:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[NH:16][C:8]([NH:10][C:11]1[S:15][N:14]=[N:13][CH:12]=1)=[O:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
16.5 g (0.075 mol) 5-phenoxycarbonylamino-1,2,3-thiadiazole are suspended in 150 ml acetone and reacted with 9.4 g (0.1 mol) of 2-aminopyridine. The reaction mass is then refluxed for 3 hours. After cooling to room temperature the formed light brown crystals are removed by suction and dried. They are then recrystallized from ethanol. There is thus obtained the above noted title compound (compound No. 1).
Workup
- temperatureThe reaction mass is then refluxed for 3 hours
- customare removed by suction
- customdried
- customThey are then recrystallized from ethanol
Sources & evidence
- ORD record
- ord-11da2a4b811c476cb0d6af7681fc096f
- Source dataset
- uspto-grants-1979_08
- Patent number
- US04163658
Reaction notes
Loading…