Sodium Hydroxide → HCID 178485064, compound
Reaction equation
C([N:4]=[C:5]([NH2:23])[NH:6][C:7]1[S:8][CH:9]=[C:10]([CH2:12][S:13][CH2:14][CH2:15][NH:16][C:17]([NH:21][CH3:22])=[N:18][C:19]#[N:20])[N:11]=1)(=O)C.[OH-].[Na+]>CO>[NH:6]([C:7]1[S:8][CH:9]=[C:10]([CH2:12][S:13][CH2:14][CH2:15][NH:16][C:17]([NH:21][CH3:22])=[N:18][C:19]#[N:20])[N:11]=1)[C:5]([NH2:23])=[NH:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 2-(2-acetylguanidino)-4-[2-(2-cyano-3-methylguanidino)ethylthiomethyl]thiazole (13.6 mg.), methanol (1 ml.) and 0.2 N aqueous sodium hydroxide solution (2 ml.) was stirred at room temperature for 20 minutes. This resulted in complete conversion to 2-guanidino-4-[2-(2-cyano-3-methylguanidino)ethylthiomethyl]thiazole, identical with the free base of the product obtained in Example 3. The free base had a m.p. 159°-161° C. on recrystallization from aqueous dimethylformamide.