2H-Benzimidazol-2-one, 1,3-dihydro-6-chloro-1-phenyl- → 4-Benzyl-2-(1-phenyl-6-chloro-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine hydrochloride

HRID 261783

Reaction equation

HRID 261783 reaction equation
[C:1]1([N:7]2[C:11]3[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:10]=3[NH:9][C:8]2=[O:17])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[CH2:19][CH:20]1[O:25][CH2:24][CH2:23][N:22]([CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:21]1>>[ClH:16].[CH2:26]([N:22]1[CH2:23][CH2:24][O:25][CH:20]([CH2:19][N:9]2[C:10]3[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=3[N:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[C:8]2=[O:17])[CH2:21]1)[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 1086532H-Benzimidazol-2-one, 1,3-dihydro-6-chloro-1-phenyl-HCID 28015624-Benzyl-2-(chloromethyl)morpholine

Product 1

HCID 706018024-Benzyl-2-(1-phenyl-6-chloro-2,3-dihydro-benzimidazol-2-on-3-yl-methyl)-morpholine hydrochloride

Procedure

The condensation of 0.1 mol of 1-phenyl-6-chloro-2,3-dihydro-benzimidazol-2-one and 0.1 mol of 2-chloromethyl-4-benzyl-morpholine is carried out in accordance with the procedure of Example 1. By washing the product with hot acetone, 28 g of 4-benzyl-2-(1-phenyl-6-chloro-2,3-dihydrobenzimidazol-2-on-3-yl-methyl)-morpholine hydrochloride are obtained, m.p. 185° C.

Workup

  1. washBy washing the product with hot acetone, 28 g of 4-benzyl-2-(1-phenyl-6-chloro-2,3-dihydrobenzimidazol-2-on-3-yl-methyl)-morpholine hydrochloride
  2. customare obtained

Sources & evidence

ORD record
ord-7e104807cca64e60889bfbda95a26f33
Source dataset
uspto-grants-1979_05
Patent number
US04152434

Linked notes

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