HCID 70050481, compound → N-[(1R,2R)-2-cyclohexylcyclopentyl]azepan-2-imine;hydrochloride

HRID 261997

Reaction equation

HRID 261997 reaction equation
[ClH:1].[C:2]1([C@H:8]2[CH2:12][CH2:11][CH2:10][C@H:9]2[NH2:13])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH:15]1([C@H:21]2CCC[C@H:22]2[NH2:26])[CH2:20][CH2:19][CH2:18]CC1>>[ClH:1].[CH:2]1([C@H:8]2[CH2:12][CH2:11][CH2:10][C@H:9]2[N:13]=[C:22]2[CH2:21][CH2:15][CH2:20][CH2:19][CH2:18][NH:26]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 70050481HCID 70050481, compoundHCID 70051154rac-(1R,2R)-2-phenylcyclopentan-1-amine hydrochloride

Product 1

HCID 145795659N-[(1R,2R)-2-cyclohexylcyclopentyl]azepan-2-imine;hydrochloride

Procedure

By the procedure of Example 1 only employing a reaction time of 29 days and substituting for cis-2-phenylcyclopentylamine hydrochloride an appropriate amount of cis-2-cyclohexylcyclopentylamine hydrochloride, the desired product was obtained, M.P. 179°-180° C.

Workup

  1. customa reaction time of 29 days

Sources & evidence

ORD record
ord-c6fd56b11605413398641f628a18dd7a
Source dataset
uspto-grants-1979_05
Patent number
US04153235

Linked notes

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