Cypenamine Hydrochloride → HCID 178477936, compound

HRID 262008

Reaction equation

HRID 262008 reaction equation
[ClH:1].[C:2]1([CH:8]2[CH2:12][CH2:11][CH2:10][CH:9]2[NH2:13])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO[C:16]1[CH2:17][CH2:18][CH2:19][N:20]=1>CCOCC>[ClH:1].[C:2]1([CH:8]2[CH2:12][CH2:11][CH2:10][CH:9]2[N:13]=[C:16]2[CH2:17][CH2:18][CH2:19][NH:20]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 21785Cypenamine HydrochlorideHCID 3534432-Methoxy-1-Pyrroline

Product 1

HCID 178477936HCID 178477936, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A slurry of 3.0 g (0.0152 mole) of powdered 2-phenylcyclopentylamine hydrochloride and 3 ml of O-methylbutyrolactim is allowed to stand at room temperature with occasional stirring for 6 days after which the material is covered with absolute ether. The solution is allowed to stand at room temperature for an additional 6 days. A precipitate forms which is collected and recrystallized from acetone-methanol and dried to give 2-[(2-phenylcyclopentyl)imino]pyrrolidine hydrochloride, M.P. 155°-158° C.

Workup

  1. customto stand at room temperature
  2. waitto stand at room temperature for an additional 6 days
  3. customA precipitate forms which is collected
  4. customrecrystallized from acetone-methanol
  5. customdried

Sources & evidence

ORD record
ord-29b0892790ac4c81802d0641a236431b
Source dataset
uspto-grants-1979_05
Patent number
US04153235

Linked notes

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