Toluene → 1,3-Bis(methoxymethyl)urea

HRID 262047

Reaction equation

HRID 262047 reaction equation
CC1(C)CC(NCC[C:11]([NH:13]N)=[O:12])CC(C)(C)N1.[CH3:18][O:19][CH2:20][N:21]=[C:22]=[O:23].[C:24]1(C)C=CC=CC=1>>[CH3:18][O:19][CH2:20][NH:21][C:22](=[O:23])[NH:13][CH2:11][O:12][CH3:24]

Participants

4

Reactant 3

HCID 1140TolueneHCID 62609Methoxymethyl isocyanateHCID 19609562HCID 19609562, compound

Product 1

HCID 88321,3-Bis(methoxymethyl)urea

Conditions

Temperature
25 °C

Procedure

36.3 parts of β-(2,2,6,6-tetramethylpiperidine-4-yl)amino-propionic acid hydrazide are dissolved in 100 parts of toluene, followed by the dropwise addition of 28.2 parts of 93% methoxymethyl isocyanate. After stirring for 1 hour at 25° C., the deposit is filtered off under suction. The filter residue is stirred with 300 parts of petroleum ether and refiltered under suction. 48 parts of colourless crystals melting at 62° to 65° C. are left after drying.

Workup

  1. filtrationthe deposit is filtered off under suction
  2. stirringThe filter residue is stirred with 300 parts of petroleum ether
  3. wait48 parts of colourless crystals melting at 62° to 65° C. are left
  4. customafter drying

Sources & evidence

ORD record
ord-8705d7da868f4f5c8106314eac885c3d
Source dataset
uspto-grants-1979_05
Patent number
US04153596

Linked notes

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