Water → 7-Bromo-5-methyl-3-phenylbenzofuran

HRID 262089

Reaction equation

HRID 262089 reaction equation
[Br:1][C:2]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:3]=1[O:4][CH2:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O.O>C(Cl)(Cl)Cl>[Br:1][C:2]1[C:3]2[O:4][CH:5]=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:14]=2[CH:15]=[C:16]([CH3:18])[CH:17]=1

Participants

4

Reactant 2

HCID 962WaterHCID 40772362-(2-Bromo-4-methylphenoxy)acetophenone

Product 1

HCID 213199287-Bromo-5-methyl-3-phenylbenzofuran

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A mixture of 700 g. of polyphosphoric acid and 100 g. of α-(2-bromo-4-methylphenoxy)acetophenone is heated at 80°-90° C. for two hours, then poured into two liters of water with stirring. Chloroform (1 liter) is added, and the phases are separated. The organic layer is washed with water, dried, then evaporated to provide 7-bromo-5-methyl-3-phenylbenzofuran as a brown oil.

Workup

  1. additionA mixture of 700 g
  2. customthe phases are separated
  3. washThe organic layer is washed with water
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-8e550f305de947eaa87715bf888aacd9
Source dataset
uspto-grants-1979_05
Patent number
US04153619

Linked notes

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